Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9309467 | 0.92 | THRA (0.39) | KDM4ETHRATHRB | |
| Iodide SCHEMBL9306528 | 0.91 | TP53 (0.38) | THRATHRBPTPN11MAPTAPAF1 | |
| Iodide SCHEMBL9305994 | 0.88 | THRA (0.40) | KDM4ETHRATHRBPTPN11MAPT | |
| Iodide SCHEMBL9306747 | 0.87 | MAPT (0.41) | KDM4ETHRATHRBMAPT | |
| Iodide SCHEMBL9308774 | 0.85 | TP53 (0.39) | THRATHRBPTPN11MAPTALDH1A1 | |
| Iodide SCHEMBL9305481 | 0.85 | THRA (0.39) | KDM4ETHRATHRBPTPN11 | |
| Iodide SCHEMBL9308427 | 0.84 | LMNA (0.42) | KDM4EMAPTAPAF1ALDH1A1LMNA | |
| Iodide SCHEMBL9307609 | 0.83 | POLB (0.41) | APAF1ALDH1A1LMNAPOLBRAD52 | |
| Iodide SCHEMBL9306815 | 0.83 | — | — | |
| Iodide SCHEMBL9306128 | 0.82 | LMNA (0.40) | KDM4ETHRATHRBMAPTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |