Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306276 | 0.91 | BCHE (0.45) | BCHEALDH1A1SMN1; SMN2 | |
| Iodide SCHEMBL9305550 | 0.90 | BCHE (0.43) | BCHE | |
| Iodide SCHEMBL9306999 | 0.88 | POLB (0.39) | MEN1KMT2ALPAR1LPAR5ALDH1A1 | |
| Iodide SCHEMBL9307210 | 0.87 | LMNA (0.37) | SMN1; SMN2 | |
| Iodide SCHEMBL9307106 | 0.86 | MAPT (0.40) | BCHEMEN1KMT2ALPAR1KDM4E | |
| Iodide SCHEMBL9307671 | 0.83 | TP53 (0.42) | BCHEMEN1KMT2A | |
| Iodide SCHEMBL9306567 | 0.80 | LMNA (0.44) | LPAR1LPAR5ALDH1A1SMN1; SMN2 | |
| Iodide SCHEMBL9307841 | 0.80 | POLB (0.43) | LPAR1LPAR5 | |
| Iodide SCHEMBL9308401 | 0.79 | LMNA (0.45) | KDM4EALDH1A1SMN1; SMN2 | |
| Iodide SCHEMBL9305698 | 0.79 | THRA (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |