Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306486 | 0.92 | POLB (0.44) | POLBTP53MAPTPLA2G4B | |
| Iodide SCHEMBL9307609 | 0.86 | POLB (0.41) | POLBTP53PLA2G4B | |
| Iodide SCHEMBL9306487 | 0.86 | POLB (0.41) | POLBPLA2G4B | |
| Iodide SCHEMBL9306058 | 0.86 | POLB (0.42) | POLBTP53PLA2G4B | |
| Iodide SCHEMBL9305981 | 0.84 | — | — | |
| Iodide SCHEMBL9307222 | 0.84 | — | — | |
| Iodide SCHEMBL9308793 | 0.83 | THRA (0.43) | THRATHRB | |
| Iodide SCHEMBL9305994 | 0.83 | THRA (0.40) | MAPTTHRATHRBPTPN11 | |
| Iodide SCHEMBL9306999 | 0.82 | POLB (0.39) | POLBTP53MAPTLPAR1LPAR5 | |
| Iodide SCHEMBL9305526 | 0.81 | KDM4E (0.38) | POLBMAPTLPAR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |