Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | NGFR | P08138 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306771 | 0.91 | NTRK1 (0.59) | P4HTMNTRK1NGFRMAPTNPC1 | |
| SCHEMBL9306916 | 0.91 | NTRK1 (0.51) | P4HTMNTRK1NGFRMAPTNPC1 | |
| SCHEMBL9306208 | 0.91 | NTRK1 (0.48) | P4HTMNTRK1NGFRMCHR1MAPT | |
| SCHEMBL9305603 | 0.87 | MAPT (0.51) | P4HTMNTRK1NGFRMAPTNPC1 | |
| SCHEMBL9307409 | 0.83 | HSD17B10 (0.60) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9307464 | 0.80 | ALPG (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9305414 | 0.79 | ELANE (0.45) | NTRK1NGFRMAPTNPC1RAB9A | |
| SCHEMBL9306585 | 0.76 | KDM4E (0.44) | NTRK1NGFRMAPTNPC1RAB9A | |
| SCHEMBL9309118 | 0.75 | NTRK1 (0.39) | NTRK1NGFRMAPTNPC1RAB9A | |
| SCHEMBL9317053 | 0.75 | NTRK1 (0.85) | P4HTMNTRK1NGFRMCHR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | claimed |
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |