Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NGFR | P08138 | 1/20 | 0.48 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306949 | 0.91 | P4HTM (0.51) | NTRK1NGFRP4HTMRAB9ANPC1 | |
| SCHEMBL9306771 | 0.90 | NTRK1 (0.59) | NTRK1NGFRP4HTMRAB9ANPC1 | |
| SCHEMBL9306916 | 0.90 | NTRK1 (0.51) | NTRK1NGFRP4HTMRAB9ANPC1 | |
| SCHEMBL9305603 | 0.86 | MAPT (0.51) | NTRK1NGFRP4HTMRAB9ANPC1 | |
| SCHEMBL9307464 | 0.79 | ALPG (0.46) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL9305414 | 0.79 | ELANE (0.45) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9317447 | 0.76 | NTRK1 (0.83) | NTRK1NGFRP4HTMRAB9ANPC1 | |
| SCHEMBL9306585 | 0.75 | KDM4E (0.44) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9306891 | 0.74 | SMN1; SMN2 (0.60) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL9309039 | 0.74 | AKR1B1 (0.51) | RAB9ANPC1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | claimed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | claimed |
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |