Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NGFR | P08138 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306916 | 0.88 | NTRK1 (0.51) | MAPTTP53POLBNTRK1NGFR | |
| SCHEMBL9309023 | 0.83 | ALDH1A1 (0.46) | RXFP1MAPTTP53POLBHPGD | |
| SCHEMBL9306949 | 0.79 | P4HTM (0.51) | MAPTTP53NTRK1NGFRALDH1A1 | |
| SCHEMBL9306771 | 0.79 | NTRK1 (0.59) | MAPTTP53NTRK1NGFRALDH1A1 | |
| SCHEMBL9306208 | 0.79 | NTRK1 (0.48) | RXFP1MAPTTP53NTRK1NGFR | |
| SCHEMBL9308366 | 0.77 | ALDH1A1 (0.50) | RXFP1MAPTPOLBHPGDALDH1A1 | |
| SCHEMBL9305603 | 0.76 | MAPT (0.51) | MAPTTP53POLBNTRK1NGFR | |
| SCHEMBL9306891 | 0.72 | SMN1; SMN2 (0.60) | ELANEMAPTTP53POLBALDH1A1 | |
| SCHEMBL9317442 | 0.70 | NTRK1 (0.85) | MAPTTP53POLBNTRK1NGFR | |
| SCHEMBL9305135 | 0.70 | MAPT (0.46) | ELANEMAPTTP53POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |