Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 6/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306262 | 0.92 | TAS2R14 (0.48) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9307171 | 0.90 | ALDH1A1 (0.47) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9305691 | 0.89 | CNR2 (0.45) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| Iodide SCHEMBL9306534 | 0.86 | ALDH1A1 (0.47) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9308634 | 0.85 | ALDH1A1 (0.45) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9307893 | 0.85 | CNR2 (0.46) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9306285 | 0.84 | ALDH1A1 (0.46) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9306653 | 0.84 | CNR2 (0.45) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| Iodide SCHEMBL9306668 | 0.84 | ALDH1A1 (0.42) | TAS2R14ALDH1A1LMNATSHRHTT | |
| Iodide SCHEMBL9306086 | 0.83 | ALDH1A1 (0.45) | TAS2R14ALDH1A1LMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |