Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 5/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307313 | 0.92 | TAS2R14 (0.47) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9306534 | 0.91 | ALDH1A1 (0.47) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9305091 | 0.89 | CNR2 (0.48) | TAS2R14TSHRHTTCNR2CNR1 | |
| Iodide SCHEMBL9307152 | 0.88 | CNR2 (0.46) | TSHRHTTCNR2CNR1POLB | |
| Iodide SCHEMBL9307171 | 0.87 | ALDH1A1 (0.47) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9306285 | 0.87 | ALDH1A1 (0.46) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9306892 | 0.87 | S1PR2 (0.42) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9308634 | 0.84 | ALDH1A1 (0.45) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9306086 | 0.84 | ALDH1A1 (0.45) | TAS2R14ALDH1A1TSHRHTTLMNA | |
| Iodide SCHEMBL9307816 | 0.83 | CNR2 (0.46) | TAS2R14TSHRHTTLMNACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |