Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NAAA | Q02083 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14128796 | 0.92 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHDAC3MEN1NPC1 | |
| Iodide SCHEMBL9308333 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHPGDHSD17B10CYP1A2 | |
| SCHEMBL1695202 | 0.85 | TP53 (0.60) | LMNATP53TSHR | |
| Iodide SCHEMBL9307614 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAHDAC3HDAC1HDAC2 | |
| SCHEMBL9565606 | 0.83 | FAAH (0.73) | NPC1RAB9A | |
| SCHEMBL9308211 | 0.82 | FAAH (0.63) | SMN1; SMN2LMNAHDAC3HDAC1HDAC2 | |
| SCHEMBL27360513 | 0.82 | HDAC3 (0.58) | HDAC3HDAC1HDAC2NAAA | |
| SCHEMBL9453351 | 0.81 | NR1H4 (0.73) | SMN1; SMN2LMNAMEN1NPC1RAB9A | |
| SCHEMBL6725374 | 0.81 | NR1H4 (0.61) | SMN1; SMN2LMNAMEN1NPC1RAB9A | |
| SCHEMBL28827967 | 0.81 | FAAH (0.65) | TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |