Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9308333 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHPGDCYP1A2MAPT | |
| Iodide SCHEMBL9305740 | 0.85 | USP2 (0.47) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9307378 | 0.84 | S1PR2 (0.52) | LMNAHDAC3 | |
| Iodide SCHEMBL9308954 | 0.84 | S1PR2 (0.52) | SMN1; SMN2 | |
| Iodide SCHEMBL9307632 | 0.84 | S1PR2 (0.52) | SMN1; SMN2 | |
| SCHEMBL9307359 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHDAC3HPGDCYP1A2 | |
| Iodide SCHEMBL9307426 | 0.79 | APOBEC3A (0.41) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9307767 | 0.79 | THRB (0.48) | SMN1; SMN2 | |
| Iodide SCHEMBL9307213 | 0.79 | THRB (0.48) | SMN1; SMN2 | |
| Iodide SCHEMBL9305869 | 0.78 | THRA (0.49) | HDAC3HPGDHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |