Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GALR2 | O43603 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162009 | 0.88 | PKM (0.53) | SMN1; SMN2ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL16183923 | 0.84 | CYP1A2 (0.54) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL28573397 | 0.81 | NPC1 (0.60) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL9268867 | 0.81 | MAPT (0.65) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14358948 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2061305 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL7092077 | 0.79 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2616932 | 0.79 | MAPT (0.77) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL753425 | 0.79 | KMT2A (0.72) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14691594 | 0.79 | HPGD (0.61) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |