Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | APAF1 | O14727 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306143 | 0.93 | S1PR2 (0.41) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9306247 | 0.90 | S1PR2 (0.42) | MAPTRAD52S1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9306470 | 0.90 | S1PR2 (0.42) | MAPTRAD52S1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9305687 | 0.89 | S1PR2 (0.42) | S1PR2S1PR1S1PR3LPAR2ATM | |
| Iodide SCHEMBL9306668 | 0.89 | ALDH1A1 (0.42) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9307893 | 0.88 | CNR2 (0.46) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9307287 | 0.87 | MAPT (0.42) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9307091 | 0.84 | LMNA (0.45) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9305573 | 0.81 | MAPT (0.40) | MAPTAPAF1LMNAKDM4EALDH1A1 | |
| Iodide SCHEMBL9306128 | 0.81 | LMNA (0.40) | MAPTAPAF1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |