Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307885 | 0.85 | BCHE (0.41) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307421 | 0.82 | GGPS1 (0.38) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9308401 | 0.82 | LMNA (0.45) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9306668 | 0.81 | ALDH1A1 (0.42) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307789 | 0.81 | MAPT (0.42) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307657 | 0.80 | BCHE (0.43) | ALDH1A1MEN1KMT2A | |
| Iodide SCHEMBL9307816 | 0.80 | CNR2 (0.46) | LMNAPOLBHTT | |
| Iodide SCHEMBL9307287 | 0.80 | MAPT (0.42) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307670 | 0.77 | MEN1 (0.40) | MAPTRAD52KDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307689 | 0.76 | GGPS1 (0.34) | GGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |