Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235665 | 0.92 | CYP3A4 (0.50) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL9408838 | 0.85 | MAPK1 (0.45) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL10356257 | 0.83 | LMNA (0.46) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL11694221 | 0.82 | MAPK1 (0.43) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL9003125 | 0.80 | ACHE (0.42) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL4107014 | 0.78 | MAPK1 (0.57) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL9307126 | 0.76 | MAPK1 (0.44) | TSHRCYP3A4MAPK1HPGDACHE | |
| SCHEMBL27690100 | 0.76 | TSHR (0.67) | TSHRCYP3A4MEN1KMT2ALMNA | |
| SCHEMBL9823401 | 0.74 | ENPP3 (0.41) | TSHRCYP3A4HPGDMEN1KMT2A | |
| SCHEMBL9928309 | 0.73 | HPGD (0.61) | MAPK1HPGDACHEBLMSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360812-A | Fused 1,2,5-oxadiazole-2-oxides and their use | CASSELLA AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |