Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17949542 | 0.89 | ALDH1A1 (0.41) | MAPK1ALDH1A1GPR84 | |
| SCHEMBL811725 | 0.84 | TP53 (0.41) | POLBKMT2AALDH1A1 | |
| SCHEMBL4352906 | 0.81 | GLA (0.38) | GLAPOLBKDM4CKMT2AKDM4E | |
| SCHEMBL19091935 | 0.81 | MAPK1 (0.38) | GLAMAPK1POLBKDM4CALDH1A1 | |
| SCHEMBL9029353 | 0.79 | GLA (0.37) | GLAPOLBKDM4CKMT2AKDM4E | |
| SCHEMBL9295900 | 0.79 | GLA (0.37) | GLAPOLBKDM4CKMT2AKDM4E | |
| SCHEMBL895 | 0.79 | GLA (0.37) | GLAPOLBKDM4CKMT2AKDM4E | |
| SCHEMBL4638662 | 0.79 | GLA (0.37) | GLAPOLBKDM4CKMT2AKDM4E | |
| SCHEMBL9198148 | 0.74 | KDM4C (0.37) | GLAMAPK1POLBKDM4CKMT2A | |
| SCHEMBL11078634 | 0.73 | GLA (0.38) | GLAMAPK1POLBKDM4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| WO-1992020673-A1 | ANTIHYPOTENSIVE BENZOFURAN DERIVATIVES WITH N-LINKED 1H-IMIDAZOLYLMETHYL-5-CARBOXAMIDE SUBSTITUENTS | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514216-A1 | Antihypotensive benzofuran derivatives with N-linked 1H-imidazolyl-methyl-5-carboxamide substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |