Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463430 | 0.90 | KDM4E (0.62) | PARP1KDM4EMMP2CHRM1TSHR | |
| Hydrochloric Acid SCHEMBL9814936 | 0.88 | KDM4E (0.60) | PARP1KDM4EMMP2CHRM1TSHR | |
| Hydrochloric Acid SCHEMBL9814926 | 0.88 | KDM4E (0.60) | PARP1KDM4EMMP2CHRM1TSHR | |
| SCHEMBL9308502 | 0.80 | PARP1 (0.51) | PARP1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL6171961 | 0.76 | PARP1 (0.59) | PARP1KDM4ESMN1; SMN2HDAC8LMNA | |
| SCHEMBL9638934 | 0.75 | KDM4E (0.63) | PARP1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL1946459 | 0.74 | KDM4E (0.54) | PARP1KDM4EMAPTNFKB1TDP1 | |
| SCHEMBL21651065 | 0.74 | KDM4E (0.57) | PARP1KDM4EMMP2CHRM1TSHR | |
| SCHEMBL7589324 | 0.74 | KDM4E (0.57) | PARP1KDM4ENPC1RAB9AHTT | |
| SCHEMBL9308505 | 0.73 | PARP1 (0.53) | PARP1KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371229-A | Nitric acid oxidation of substituted quinoline precursor using manganese catalyst | AMERICAN CYANAMID COMPANY (US) | 1994-12-06 | — | — | US | disclosed |