Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463430 | 0.82 | KDM4E (0.62) | KDM4EPDE10APARP1MMP2CHRM1 | |
| SCHEMBL8838482 | 0.81 | PDE10A (0.44) | KDM4EPDE10APARP1 | |
| SCHEMBL8811070 | 0.81 | HPGDS (0.56) | PDE10APARP1MEN1KMT2ANPC1 | |
| SCHEMBL8099182 | 0.81 | PDE4A (0.40) | KDM4EPARP1HTT | |
| Hydrochloric Acid SCHEMBL9814936 | 0.81 | KDM4E (0.60) | KDM4EPDE10APARP1MMP2CHRM1 | |
| Hydrochloric Acid SCHEMBL9814926 | 0.81 | KDM4E (0.60) | KDM4EPDE10APARP1MMP2CHRM1 | |
| SCHEMBL28076889 | 0.80 | PARP1 (0.56) | KDM4EPARP1 | |
| SCHEMBL21651065 | 0.78 | KDM4E (0.57) | KDM4EPARP1MMP2CHRM1TSHR | |
| Bromide SCHEMBL7469974 | 0.77 | KDM4E (0.55) | KDM4EPARP1MMP2CHRM1TSHR | |
| SCHEMBL8838403 | 0.77 | PDE10A (0.51) | KDM4EPDE10APARP1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067380-C | Method for conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID CO (US) | 2001-06-20 | — | — | CN | claimed |
| EP-0744399-B1 | Conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID CO (US) | 2000-10-25 | — | — | EP | claimed |
| CN-1146989-A | Method for conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID CO (US) | 1997-04-09 | — | — | CN | claimed |
| EP-0548520-B1 | Process for the manufacture of 2-alkoxymethylacrolein and its use for preparing 3-alkoxymethyl quinolines | AMERICAN CYANAMID CO (US) | 1997-01-29 | — | — | EP | claimed |
| US-5597924-A | Coversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID COMPANY (US) | 1997-01-28 | — | — | US | claimed |
| EP-0744399-A2 | Conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | American Cyanamid Company (US) | 1996-11-27 | — | — | EP | claimed |
| US-5281713-A | Process for the manufacture of 2-alkoxymethylacrolein | AMERICAN CYANAMID COMPANY (US) | 1994-01-25 | — | — | US | claimed |
| EP-0548520-A2 | Process for the manufacture of 2-alkoxymethylacrolein and its use for preparing 3-alkoxymethyl quinolines | AMERICAN CYANAMID COMPANY (US) | 1993-06-30 | — | — | EP | claimed |
| JP-9003048-A | — | — | None | — | — | JP | disclosed |
| CN-1130344-C | Substituted quinoline herbicide intermediates and process | AMERICAN CYANAMID CO (US) | 2003-12-10 | — | — | CN | disclosed |
| EP-0747362-B1 | Substituted quinoline herbicide intermediates and process | BASF AG (DE) | 2002-10-30 | — | — | EP | disclosed |
| CN-1067380-C | Method for conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID CO (US) | 2001-06-20 | — | — | CN | disclosed |
| EP-0744399-B1 | Conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | AMERICAN CYANAMID CO (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5633380-A | DEHALOGENATED, DESALTED HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1997-05-27 | — | — | US | disclosed |
| CN-1138034-A | Substituted quinoline herbicide intermediates and process | AMERICAN CYANAMID CO (US) | 1996-12-18 | — | — | CN | disclosed |
| EP-0747362-A1 | Substituted quinoline herbicide intermediates and process | American Cyanamid Company (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0744399-A2 | Conversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines | American Cyanamid Company (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5506360-A | Process for the manufacture of 2-alkoxymethylacrolein | AMERICAN CYANAMID COMPANY (US) | 1996-04-09 | — | — | US | disclosed |
| US-5281713-A | Process for the manufacture of 2-alkoxymethylacrolein | AMERICAN CYANAMID COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0548520-A2 | Process for the manufacture of 2-alkoxymethylacrolein and its use for preparing 3-alkoxymethyl quinolines | AMERICAN CYANAMID COMPANY (US) | 1993-06-30 | — | — | EP | disclosed |