Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | BCL9 | O00512 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999056 | 0.91 | MAPT (0.51) | MAPTCRHBPCRHR2L3MBTL1BCL9 | |
| SCHEMBL2672728 | 0.89 | MAPT (0.59) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL960875 | 0.85 | MAPT (0.55) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL9001515 | 0.84 | MAPT (0.54) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL9710075 | 0.81 | MMP8 (0.50) | MAPTALDH1A1LMNAMMP8KMT2A | |
| SCHEMBL19413788 | 0.81 | MAPT (0.50) | MAPTCRHBPCRHR2L3MBTL1BCL9 | |
| SCHEMBL14999956 | 0.81 | MAPT (0.51) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL1522685 | 0.80 | MMP8 (0.64) | L3MBTL1ALDH1A1KDM4ELMNAMMP8 | |
| SCHEMBL15664802 | 0.80 | MAPT (0.50) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL5160654 | 0.79 | MAPT (0.51) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358950-A | Useful in treatment of cardiovascular diseases | LABORATOIRES UPSA (FR) | 1994-10-25 | — | — | US | disclosed |
| US-5217973-A | Treatment of cardiovascular diseases such as hypertension, cardiac insufficiency and diseases of the arterial walls | LABORATOIRES UPSA (FR) | 1993-06-08 | — | — | US | disclosed |