Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 3/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534123 | 0.88 | MMP8 (0.52) | MMP8HDAC1HDAC6KMT2AMAPT | |
| SCHEMBL27747 | 0.88 | MMP8 (0.58) | MMP8HDAC1HDAC6KMT2AMAPT | |
| SCHEMBL1522685 | 0.85 | MMP8 (0.64) | MMP8KMT2AMAPK1LMNAMEN1 | |
| SCHEMBL2426124 | 0.83 | MMP8 (0.54) | MMP8HDAC1HDAC6KMT2AMAPT | |
| SCHEMBL9308568 | 0.81 | MAPT (0.52) | MMP8KMT2AMAPTLMNAMEN1 | |
| SCHEMBL3708718 | 0.80 | HDAC1 (0.50) | MMP8HDAC1HDAC6KMT2AALDH1A1 | |
| SCHEMBL8693477 | 0.79 | KMT2A (0.43) | KMT2AMAPTMAPK1LMNANPSR1 | |
| SCHEMBL4415181 | 0.79 | MMP8 (0.40) | MMP8KMT2AMAPK1ALDH1A1TP53 | |
| SCHEMBL15261926 | 0.79 | SMN1; SMN2 (0.50) | MMP8MAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL1312803 | 0.79 | MMP8 (0.62) | MMP8KMT2AMAPK1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |