Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15714322 | 0.95 | NPC1 (0.54) | MAPTMDM2CRHBPCRHR2MMP8 | |
| SCHEMBL2672728 | 0.87 | MAPT (0.59) | MAPTCRHBPCRHR2MMP8L3MBTL1 | |
| SCHEMBL6250712 | 0.85 | MDM2 (0.69) | MAPTMDM2MMP8L3MBTL1ALDH1A1 | |
| SCHEMBL960875 | 0.83 | MAPT (0.55) | MAPTCRHBPCRHR2MMP8L3MBTL1 | |
| SCHEMBL9001515 | 0.82 | MAPT (0.54) | MAPTCRHBPCRHR2MMP8L3MBTL1 | |
| SCHEMBL27429943 | 0.81 | LDHA (0.59) | MAPTMDM2MMP8L3MBTL1ALDH1A1 | |
| SCHEMBL3097166 | 0.80 | ALDH1A1 (0.52) | MAPTCRHBPCRHR2MMP8L3MBTL1 | |
| SCHEMBL17895425 | 0.80 | CA2 (0.62) | MDM2MMP8 | |
| SCHEMBL3936094 | 0.80 | RAB9A (0.60) | MAPTALDH1A1KDM4EGAANPC1 | |
| SCHEMBL7609219 | 0.80 | RAB9A (0.60) | MAPTALDH1A1KDM4EGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128418-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTING AND TREATING OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-05-08 | — | — | US | disclosed |
| EP-2682392-A2 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTING AND TREATING OSTEOPOROSIS CONTAINING SAME | EWHA University-Industry Collaboration Foundation (KR) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128418-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTING AND TREATING OSTEOPOROSIS CONTAINING SAME | PTH1R, SOST, CYP24A1 | MAPT 3279/4885MDM2 3428/4885CRHBP 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.