Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinalizarin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.80 |
| ▸ | MAPT | P10636 | 6/20 | 0.80 |
| ▸ | MEN1 | O00255 | 6/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.80 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | RECQL | P46063 | 3/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | APEX1 | P27695 | 2/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.80 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.80 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.80 |
| ▸ | BCL2 | P10415 | 2/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anthrarufin SCHEMBL9308318 | 0.97 | MAPT (0.86) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29929513 | 0.93 | MAOA (0.77) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6901176 | 0.93 | MAOA (0.77) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| 1-Hydroxyanthraquinone SCHEMBL9317010 | 0.91 | MAPT (0.80) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| Danthron SCHEMBL9317014 | 0.91 | MAPT (0.80) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29929596 | 0.91 | MAOA (0.76) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3185453 | 0.91 | MAOA (0.76) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30695841 | 0.91 | MAOA (0.76) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| Athraquinones A SCHEMBL18614 | 0.89 | MAPT (1.00) | MAOAMAPTMEN1KMT2AALDH1A1 | |
| Athraquinones A SCHEMBL21114402 | 0.89 | MAPT (1.00) | MAOAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5316768-A | Anthraquinone or anthrone compounds | MURDOCK INTERNATIONAL CORPORATION (US) | 1994-05-31 | — | — | US | disclosed |