Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Danthron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.80 |
| ▸ | MAOA | P21397 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | MAOB | P27338 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.76 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | RECQL | P46063 | 4/20 | 0.63 |
| ▸ | APEX1 | P27695 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Hydroxyanthraquinone SCHEMBL9317010 | 1.00 | MAPT (0.80) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| Anthrarufin SCHEMBL11422341 | 0.96 | MAPT (0.83) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| SCHEMBL3198327 | 0.94 | MAOA (0.86) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| SCHEMBL30695844 | 0.94 | MAOA (0.86) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| 1-Hydroxyanthraquinone SCHEMBL145303 | 0.94 | MAOA (0.86) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| Anthrarufin SCHEMBL25355428 | 0.94 | MAOA (0.86) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| 1-Hydroxyanthraquinone SCHEMBL30912125 | 0.94 | MAOA (0.86) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| 1-Hydroxyanthraquinone SCHEMBL1893347 | 0.92 | MAOA (0.83) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| Quinalizarin SCHEMBL9308575 | 0.91 | MAOA (0.80) | MAPTMAOAALDH1A1TDP1MAPK1 | |
| Danthron SCHEMBL29356886 | 0.89 | MAPT (1.00) | MAPTMAOAALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322634-A | Electrorheological fluids comprising phenoxy organometallic salt particulate | FORD MOTOR COMPANY (US) | 1994-06-21 | — | — | US | claimed |