Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | HTR5A | P47898 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585868 | 0.83 | DRD2 (0.71) | DRD2MEN1CYP1A2HTR1ATSHR | |
| SCHEMBL9145254 | 0.83 | DRD2 (0.71) | DRD2MEN1CYP1A2HTR1ATSHR | |
| Bromide SCHEMBL15662725 | 0.82 | DRD2 (0.69) | DRD2HTR1A | |
| SCHEMBL10445855 | 0.81 | DRD2 (0.68) | DRD2HTR1A | |
| SCHEMBL9308579 | 0.80 | DRD2 (0.66) | DRD2MEN1CYP1A2HTR1ATSHR | |
| SCHEMBL9308578 | 0.80 | DRD2 (0.66) | DRD2MEN1CYP1A2HTR1ATSHR | |
| SCHEMBL9018937 | 0.79 | DRD2 (0.65) | DRD2HTR1ADRD3 | |
| Bromide SCHEMBL9310041 | 0.79 | DRD2 (0.64) | DRD2MEN1CYP1A2HTR1ATSHR | |
| Bromide SCHEMBL9310045 | 0.79 | DRD2 (0.64) | DRD2MEN1CYP1A2HTR1ATSHR | |
| SCHEMBL29389256 | 0.77 | DRD2 (1.00) | DRD2MEN1CYP1A2HTR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452390-B1 | HALO SUBSTITUTED AMINOTETRALINS | UPJOHN CO (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5225596-A | Halo substituted aminotetralins | THE UPJOHN COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5214156-A | Central nervous system disorders, dopamime receptor activity | THE UPJOHN COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0334538-B1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0407416-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-16 | — | — | EP | disclosed |
| WO-1990007490-A1 | HALO SUBSTITUTED AMINOTETRALINS | THE UPJOHN COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |
| WO-1989009050-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1989-10-05 | — | — | WO | disclosed |