Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.54 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 9/20 | 0.64 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9310041 | 1.00 | DRD2 (0.64) | DRD2DRD3LMNAMEN1KMT2A | |
| SCHEMBL9308578 | 0.99 | DRD2 (0.66) | DRD2DRD3LMNAMEN1KMT2A | |
| SCHEMBL9308579 | 0.99 | DRD2 (0.66) | DRD2DRD3LMNAMEN1KMT2A | |
| SCHEMBL9307668 | 0.80 | DRD2 (0.63) | DRD2DRD3MEN1KMT2ADRD4 | |
| Hydrochloric Acid SCHEMBL9309091 | 0.79 | DRD2 (0.61) | DRD2DRD3MEN1KMT2ADRD4 | |
| Hydrochloric Acid SCHEMBL9309093 | 0.79 | DRD2 (0.61) | DRD2DRD3MEN1KMT2ADRD4 | |
| SCHEMBL9355384 | 0.79 | DRD2 (1.00) | DRD2DRD3MEN1KMT2ADRD4 | |
| SCHEMBL10896490 | 0.76 | DRD2 (0.54) | DRD2DRD3LMNAMEN1KMT2A | |
| SCHEMBL6363170 | 0.75 | DRD2 (0.53) | DRD2DRD3LMNAMEN1KMT2A | |
| SCHEMBL6554222 | 0.75 | DRD2 (0.53) | DRD2DRD3LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286747-A | 1-alkyl-2-aminotetralin derivatives | Carlsson, Per A. E. (SE) | 1994-02-15 | — | — | US | disclosed |
| US-4876284-A | CENTRAL NERVOUS SYSTEM DISORDERS | PER ARVID EMIL CARLSSON (SE) | 1989-10-24 | — | — | US | disclosed |
| EP-0064964-B1 | THERAPEUTICALLY USEFUL 1-ALKYL-2-AMINOTETRALIN DERIVATIVES | Astra Läkemedel Aktiebolag (SE) | 1984-08-08 | — | — | EP | disclosed |
| EP-0064964-A1 | Therapeutically useful 1-alkyl-2-aminotetralin derivatives | Astra Läkemedel Aktiebolag (SE) | 1982-11-17 | — | — | EP | disclosed |