Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | RORA | P35398 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27409225 | 0.75 | TTR (0.39) | TTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27411718 | 0.74 | LMNA (0.40) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL30002016 | 0.73 | AXL (0.52) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL10341044 | 0.71 | MAP2K2 (0.49) | KDM4EALDH1A1HPGDMAP2K2MAP2K1 | |
| SCHEMBL713899 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL12254547 | 0.70 | EGLN1 (0.60) | EGLN1MEN1KMT2A | |
| SCHEMBL20411991 | 0.70 | HPGD (0.50) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL13450536 | 0.69 | ALDH1A1 (0.78) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL14423413 | 0.69 | TP53 (0.54) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL24172646 | 0.69 | MEN1 (0.71) | KDM4EALDH1A1HPGDEGLN1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| CN-1077192-A | The 2-oxoquinoline derivatives | MERCK PATENT GMBH (DE) | 1993-10-13 | — | — | CN | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |