Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 13/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CDK11B | P21127 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18548855 | 0.88 | HSD17B10 (0.47) | AXLHSD17B10SMN1; SMN2AURKADDR1 | |
| SCHEMBL18549350 | 0.85 | ALDH1A1 (0.57) | AXLHSD17B10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10085033 | 0.83 | MAPT (0.47) | AXLHSD17B10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24737265 | 0.80 | PGR (0.43) | AXLHSD17B10AURKADDR1AURKB | |
| SCHEMBL30001575 | 0.77 | SMN1; SMN2 (0.48) | AXLHSD17B10SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL30002195 | 0.77 | KDM4E (0.61) | HSD17B10NTRK1KDM4EALDH1A1HPGD | |
| SCHEMBL20308897 | 0.75 | MEN1 (0.47) | AXLHSD17B10AURKADDR1AURKB | |
| SCHEMBL18550514 | 0.75 | AXL (0.41) | AXLHSD17B10SMN1; SMN2AURKADDR1 | |
| SCHEMBL10086142 | 0.73 | ALDH1A1 (0.58) | HSD17B10SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL9308627 | 0.73 | TTR (0.41) | HSD17B10KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253283-A1 | PROTEIN KINASE DEGRADANT AND USE THEREOF | 中国科学院上海有机化学研究所 | 2022-12-08 | — | — | WO | disclosed |