Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.42 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059172 | 0.88 | POLB (0.37) | LMNAMAPTALDH1A1HCAR2CYP2D6 | |
| SCHEMBL50555 | 0.88 | POLB (0.37) | LMNAMAPTALDH1A1HCAR2CYP2D6 | |
| SCHEMBL27902025 | 0.82 | POLB (0.34) | LMNAKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27926854 | 0.81 | HCAR2 (0.38) | LMNAKMT2AMAPTALDH1A1HCAR2 | |
| SCHEMBL30931450 | 0.78 | POLB (0.38) | LMNAKMT2AHDAC4ALDH1A1CYP2D6 | |
| SCHEMBL6700611 | 0.76 | POLB (0.39) | LMNAKMT2AMAPTHDAC3HDAC4 | |
| SCHEMBL23707006 | 0.74 | MAPT (0.57) | LMNAKMT2AMAPTHDAC3HDAC4 | |
| SCHEMBL89374 | 0.73 | POLB (0.49) | LMNAKMT2AMAPTALDH1A1CYP2D6 | |
| SCHEMBL8694188 | 0.73 | POLB (0.49) | LMNAKMT2AMAPTALDH1A1CYP2D6 | |
| SCHEMBL27926152 | 0.73 | ALDH1A1 (0.38) | LMNAKMT2AMAPTALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5290817-A | Antiinflammatory, antiallergenic agents | THE DU PONT MERCK PHARMACEUTICAL CO. (US) | 1994-03-01 | — | — | US | disclosed |
| US-4167640-A | 5-Fluoro-2-methyl-ind-1-ene-3-acetic acid | MERCK & CO., INC. (US) | 1979-09-11 | — | — | US | disclosed |
| US-4123457-A | 2-Methyl-5-fluoro-indanol-3-acetic acid | MERCK & CO., INC. (US) | 1978-10-31 | — | — | US | disclosed |
| US-3998875-A | PROCESS OF PREPARING 5-FLUORO-2-METHYL-1-(PARAMETHYLSULFINYLBENZYLIDENE)-INDENYL-3-ACETIC ACID | MERCK & CO., INC. (US) | 1976-12-21 | — | — | US | disclosed |