Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP2 | P12104 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2531253 | 0.73 | LMNA (0.68) | LMNANPSR1AXLFABP4KMT2A | |
| SCHEMBL3907258 | 0.73 | AXL (0.44) | LMNANPSR1AXLPTPN2PTPN1 | |
| SCHEMBL17908025 | 0.70 | LMNA (1.00) | LMNANPSR1AXLFABP4KMT2A | |
| SCHEMBL27335387 | 0.69 | LMNA (0.45) | LMNANPSR1AXLPTPN2PTPN1 | |
| SCHEMBL16396059 | 0.69 | ACLY (0.57) | LMNANPSR1AXLPTPN2PTPN1 | |
| SCHEMBL2556706 | 0.68 | ALDH1A1 (0.48) | PTPN1FABP4KMT2AFABP3FABP5 | |
| SCHEMBL159280 | 0.67 | — | — | |
| SCHEMBL7858740 | 0.67 | — | — | |
| SCHEMBL11472500 | 0.67 | LMNA (0.65) | LMNANPSR1PTPN2PTPN1FABP4 | |
| SCHEMBL16346833 | 0.67 | LMNA (0.64) | LMNANPSR1AXLPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5300655-A | 2-carboxy-thiophene derivatives | PFIZER INC. (US) | 1994-04-05 | — | — | US | disclosed |