Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309368 | 0.93 | MAPK1 (0.34) | TSHR | |
| SCHEMBL9309041 | 0.92 | — | — | |
| SCHEMBL9311003 | 0.91 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9309605 | 0.88 | MAPK1 (0.36) | — | |
| SCHEMBL9695744 | 0.88 | KDM4E (0.34) | TSHRVDR | |
| SCHEMBL9308876 | 0.85 | MAPK1 (0.36) | TSHR | |
| SCHEMBL9677392 | 0.84 | BRD4 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9310813 | 0.83 | AGTR2 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9859908 | 0.82 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9309904 | 0.82 | MAPK1 (0.36) | TSHRAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| WO-1992016552-A1 | 1-IMIDAZOLGEMETHYL BENZOFURAN DERIVATIVES AS INHIBITORS OF ANGIOTENSIN II ACTIVITY | GLAXO GROUP LIMITED (GB) | 1992-10-01 | — | — | WO | disclosed |
| EP-0505954-A1 | N-Imidazolylmethyl benzofuran derivatives as inhibitors of angiotensin II activity | GLAXO GROUP LIMITED (GB) | 1992-09-30 | — | — | EP | disclosed |