Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309923 | 0.91 | AGTR1 (0.67) | AGTR1AGTR2S1PR1 | |
| SCHEMBL9571416 | 0.83 | ALDH1A1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9310171 | 0.83 | AGTR1 (0.52) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9309546 | 0.82 | AGTR1 (0.54) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL10576800 | 0.82 | AGTR1 (0.60) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846708 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9310178 | 0.80 | AGTR1 (0.53) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846680 | 0.77 | AGTR1 (0.49) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846700 | 0.76 | AGTR1 (0.52) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846722 | 0.76 | AGTR1 (0.52) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |