Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846773 | 0.86 | AGTR1 (0.45) | AGTR1AGTR2NR1H2NR1H3 | |
| SCHEMBL10576800 | 0.78 | AGTR1 (0.60) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9309540 | 0.77 | AGTR1 (0.54) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846708 | 0.77 | AGTR1 (0.54) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9309546 | 0.76 | AGTR1 (0.54) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846700 | 0.75 | AGTR1 (0.52) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846763 | 0.74 | NR1H2 (0.51) | NR1H2NR1H3 | |
| SCHEMBL9310178 | 0.72 | AGTR1 (0.53) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL9846704 | 0.72 | TLR8 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9846722 | 0.72 | AGTR1 (0.52) | AGTR1AGTR2HSP90AA1HSP90B1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |