Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308252 | 0.86 | TSHR (0.37) | TSHRMAOBGABRA1GABRG2GABRB3 | |
| SCHEMBL9308818 | 0.84 | KDM4E (0.34) | PTGESTSHRMAOBGABRA1GABRG2 | |
| SCHEMBL9312060 | 0.83 | AR (0.39) | TSHRGABRA1GABRG2GABRB3GABRA2 | |
| SCHEMBL9309635 | 0.82 | CSNK2A2 (0.40) | TSHRMAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL27370072 | 0.82 | PTGES (0.34) | PTGESESR2CTSAKDM4EALDH1A1 | |
| SCHEMBL9310253 | 0.81 | PTGES (0.35) | PTGESTSHRESR2ALDH1A1CYP1A2 | |
| SCHEMBL9309961 | 0.81 | AR (0.34) | TSHRMAOBGABRA1GABRG2GABRB3 | |
| SCHEMBL9480651 | 0.80 | PTGES (0.34) | PTGESESR2CSNK2A1NPC1RAB9A | |
| SCHEMBL27370069 | 0.80 | PTGES (0.34) | PTGESESR2CTSANPC1RAB9A | |
| SCHEMBL9308247 | 0.76 | KCNH2 (0.46) | TSHRKDM4EALDH1A1HPGDCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| EP-0559724-A1 | BENZOFURAN AND BENZTHIOPHENE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009600-A1 | BENZOFURAN AND BENZTHIOPHENE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-06-11 | — | — | WO | disclosed |
| CN-1052672-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1991-07-03 | — | — | CN | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |