Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312060 | 0.88 | AR (0.39) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9309638 | 0.84 | PTGES (0.36) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9311398 | 0.84 | PTGES (0.32) | KDM4EALDH1A1HPGDTSHRESR2 | |
| SCHEMBL9308252 | 0.83 | TSHR (0.37) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9309961 | 0.79 | AR (0.34) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9308810 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1HPGDTSHRGABRA1 | |
| SCHEMBL9309635 | 0.77 | CSNK2A2 (0.40) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL9308247 | 0.74 | KCNH2 (0.46) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL9312055 | 0.72 | AR (0.38) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8550394 | 0.71 | TSHR (0.36) | KDM4EALDH1A1HPGDGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |