SCHEMBL9309664

SCHEMBL9309664

CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1ccc2oc(-c3ccccc3N)c(Br)c2c1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.66
AGTR2 P50052 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9308205 0.95 AGTR1 (0.59) AGTR1
SCHEMBL9310333 0.92 AGTR1 (0.55) AGTR1
SCHEMBL9859264 0.91 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL7299689 0.90 AGTR1 (0.69) AGTR1AGTR2
SCHEMBL9309646 0.90 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL9311385 0.88 AGTR1 (0.52) AGTR1
SCHEMBL9309997 0.88 AGTR1 (0.64) AGTR1
SCHEMBL9309977 0.87 AGTR1 (0.71) AGTR1AGTR2
SCHEMBL9309276 0.87 AGTR1 (0.68) AGTR1AGTR2
SCHEMBL9308979 0.85 AGTR1 (0.59) AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5374646-A Treatment or prophylasix of hypertension and diseases associated with cognitive disorders GLAXO GROUP LIMITED (GB) 1994-12-20 US disclosed
CN-1052672-A Benzofuran derivative GLAXO GROUP LTD (GB) 1991-07-03 CN disclosed