SCHEMBL9309977

SCHEMBL9309977

CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3C(=O)OCC)c(Br)c2c1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.71
AGTR2 P50052 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7301212 0.94 AGTR1 (0.69) AGTR1AGTR2
SCHEMBL7299689 0.94 AGTR1 (0.69) AGTR1AGTR2
SCHEMBL9310803 0.93 AGTR1 (0.72) AGTR1AGTR2
SCHEMBL9309997 0.93 AGTR1 (0.64) AGTR1
SCHEMBL9309106 0.92 AGTR1 (0.77) AGTR1AGTR2
SCHEMBL9309646 0.92 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL9714902 0.88 AGTR1 (0.59) AGTR1
SCHEMBL9309664 0.87 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL9859264 0.87 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL9695832 0.87 AGTR1 (0.62) AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1052672-A Benzofuran derivative GLAXO GROUP LTD (GB) 1991-07-03 CN claimed
EP-0434249-A2 Benzofuran derivatives GLAXO GROUP LIMITED (GB) 1991-06-26 EP claimed
US-5374646-A Treatment or prophylasix of hypertension and diseases associated with cognitive disorders GLAXO GROUP LIMITED (GB) 1994-12-20 US disclosed
CN-1052672-A Benzofuran derivative GLAXO GROUP LTD (GB) 1991-07-03 CN disclosed
EP-0434249-A2 Benzofuran derivatives GLAXO GROUP LIMITED (GB) 1991-06-26 EP disclosed