Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303033 | 0.89 | NPC1 (0.46) | ALOX5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7302152 | 0.88 | KDM4E (0.46) | ALOX5NPC1RAB9ARXFP1KDM4E | |
| SCHEMBL9313939 | 0.88 | ALOX5 (0.50) | ALOX5PTGS2KDM4EALDH1A1GAA | |
| SCHEMBL7302852 | 0.85 | KDM4E (0.44) | ALOX5NPC1RAB9APTGS2KDM4E | |
| SCHEMBL9309854 | 0.85 | TSHR (0.47) | ALOX5NPC1RAB9ARXFP1KDM4E | |
| SCHEMBL7312942 | 0.84 | KDM4E (0.62) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL9308867 | 0.77 | AGTR1 (0.49) | — | |
| SCHEMBL9571330 | 0.76 | CYP4F2 (0.53) | ALOX5PTGS2KDM4EALDH1A1GAA | |
| SCHEMBL9309360 | 0.76 | AGTR1 (0.51) | — | |
| SCHEMBL8544446 | 0.76 | HTT (0.45) | ALOX5KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |