Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302158 | 0.88 | SLC6A3 (0.46) | TSHRNPC1MEN1KMT2AKDM4E | |
| SCHEMBL9313945 | 0.87 | CYP4F2 (0.48) | TSHRMEN1KMT2AKDM4EALOX5 | |
| SCHEMBL7302856 | 0.85 | AR (0.38) | NPC1MEN1KMT2AKDM4EALOX5 | |
| SCHEMBL9309848 | 0.85 | ALOX5 (0.53) | TSHRNPC1MEN1KMT2AKDM4E | |
| SCHEMBL7312950 | 0.84 | KDM4E (0.53) | TSHRNPC1MEN1KMT2AKDM4E | |
| SCHEMBL9311621 | 0.77 | TSHR (0.48) | TSHRNPC1MEN1KMT2AKDM4E | |
| SCHEMBL9710721 | 0.76 | ALDH1A1 (0.47) | TSHRNPC1MEN1KMT2AKDM4E | |
| SCHEMBL8544448 | 0.75 | KMT2A (0.46) | TSHRNPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7314778 | 0.75 | TSHR (0.46) | TSHRNPC1MEN1KMT2AMAPK1 | |
| SCHEMBL7303033 | 0.74 | NPC1 (0.46) | TSHRNPC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| CN-1052672-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1991-07-03 | — | — | CN | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |