Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310086 | 1.00 | CES2 (0.42) | CES2CES1APOBEC3AAPOBEC3GFAAH | |
| SCHEMBL4935734 | 0.85 | CYP1A2 (0.41) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL4935739 | 0.85 | CYP1A2 (0.41) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL7766368 | 0.83 | SOAT1 (0.41) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL7766360 | 0.83 | SOAT1 (0.41) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL7766372 | 0.83 | SOAT1 (0.41) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL1126713 | 0.83 | APOBEC3A (0.36) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL1126715 | 0.83 | APOBEC3A (0.36) | APOBEC3AAPOBEC3GFAAHMAPTALDH1A1 | |
| SCHEMBL2914885 | 0.83 | ALDH1A1 (0.46) | APOBEC3AAPOBEC3GMAPTALDH1A1NPSR1 | |
| SCHEMBL27436081 | 0.80 | APOBEC3A (0.35) | CES2CES1APOBEC3AAPOBEC3GFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| CN-1052672-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1991-07-03 | — | — | CN | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |