Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP4 | P49662 | 1/20 | 0.54 |
| ▸ | CASP5 | P51878 | 1/20 | 0.54 |
| ▸ | VEGFA | P15692 | 1/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9311548 | 0.91 | POLB (0.60) | VEGFAEGLN1SIGMAR1POLBALDH1A1 | |
| SCHEMBL7146756 | 0.87 | VEGFA (0.63) | DRD2CASP1CASP5VEGFAEGLN1 | |
| SCHEMBL27634139 | 0.80 | HTR1A (0.52) | HTR1ADRD2CASP1CASP4CASP5 | |
| SCHEMBL27830575 | 0.79 | CYP1A2 (0.57) | VEGFAEGLN1CYP1A2MAPTALDH1A1 | |
| SCHEMBL9311956 | 0.79 | CYP1A2 (0.43) | VEGFAEGLN1CYP1A2ALDH1A1LMNA | |
| SCHEMBL10754483 | 0.78 | HTR1A (0.64) | HTR1AVEGFAEGLN1SIGMAR1MAPT | |
| SCHEMBL15004980 | 0.77 | CYP1A2 (0.54) | VEGFAEGLN1CYP1A2MAPTALDH1A1 | |
| SCHEMBL6056974 | 0.76 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL7264546 | 0.76 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL13150782 | 0.76 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |