SCHEMBL9310355

SCHEMBL9310355

CCn1c(C)cc(-c2nnn[nH]2)c1-c1ccc(Cn2c(OC)nc3c(C)cc(C)nc32)cc1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 5/20 0.44
AGTR1 P30556 4/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9310177 0.92 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL8942974 0.88 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL8829242 0.88 AGTR2 (0.55) AGTR2AGTR1
Hydrochloric Acid SCHEMBL8829210 0.87 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL9043021 0.86 AGTR1 (0.56) AGTR2AGTR1
SCHEMBL8566867 0.86 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL9597307 0.83 AGTR2 (0.44) AGTR2AGTR1
SCHEMBL9310592 0.82 AGTR1 (0.42) AGTR2AGTR1
SCHEMBL9041756 0.80 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL9847835 0.80 AGTR1 (0.47) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5354759-A Angiotenin II antagonizing heterocyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-10-11 US disclosed
EP-0553682-A1 Imidazo 4,5-b pyridine derivatives as Angiotensin II antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-08-04 EP disclosed