Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037274 | 0.89 | PDE10A (0.65) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| SCHEMBL23457927 | 0.85 | PDE10A (0.76) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| SCHEMBL4429531 | 0.80 | PDE10A (0.75) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| SCHEMBL9312020 | 0.79 | PDE10A (0.74) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| Papaverine SCHEMBL29387160 | 0.78 | PDE10A (1.00) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| Papaverine SCHEMBL29360983 | 0.78 | PDE10A (1.00) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| Papaverine SCHEMBL9551009 | 0.78 | PDE10A (1.00) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| Papaverine SCHEMBL34702 | 0.78 | PDE10A (1.00) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| Hydrochloric Acid SCHEMBL9313216 | 0.77 | PDE10A (0.76) | PDE10APDE3APDE3BCYP3A4MAPK1 | |
| SCHEMBL23457926 | 0.77 | PDE10A (0.53) | PDE10APDE3APDE3BCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE34630-E | Antagonist for platelet activating factor | EUROCELTIQUE, S.A. (LU) | 1994-06-07 | — | — | US | disclosed |
| EP-0422328-A2 | Substituted isoquinolines and their use | Euro-Celtique S.A. (LU) | 1991-04-17 | — | — | EP | disclosed |
| US-4956371-A | PLATELET ACTIVATING FACTOR | EUROCELTIQUE, S.A. (LU) | 1990-09-11 | — | — | US | disclosed |