Papaverine

Papaverine

SCHEMBL29387160

COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 14/20 1.00
PDE3A Q14432 10/20 1.00
PDE3B Q13370 9/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
CYP3A4 P08684 4/20 1.00
MAPK1 P28482 4/20 1.00
LMNA P02545 3/20 1.00
USP2 O75604 2/20 1.00
ALDH1A1 P00352 2/20 1.00
HIF1A Q16665 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2C9 P11712 2/20 1.00
TSHR P16473 2/20 1.00
PDE4A P27815 2/20 1.00
KCNH2 Q12809 2/20 1.00
PDE4D Q08499 2/20 1.00
PDE2A O00408 1/20 1.00
ABCC4 O15439 1/20 1.00
PDE5A O76074 1/20 1.00
ABCB11 O95342 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Papaverine SCHEMBL34702 1.00 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL9551009 1.00 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL29360983 1.00 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL28169527 0.99 PDE10A (0.97) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL29696479 0.99 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL8691148 0.99 PDE10A (0.97) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL677440 0.99 PDE10A (0.97) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL29356374 0.99 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL9614479 0.99 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4
Papaverine SCHEMBL5500363 0.99 PDE10A (1.00) PDE10APDE3APDE3BSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12175886-B2 Fake blood for use in simulated surgical procedures Intuitive Surgical Operations, Inc. (US) 2024-12-24 US claimed
US-11771695-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-10-03 US claimed
US-20230126091-A1 FAKE BLOOD FOR USE IN SIMULATED SURGICAL PROCEDURES Intuitive Surgical Operations, Inc. 2023-04-27 US claimed
EP-3385252-B1 CANNABINOID RECEPTOR MODULATORS ARENA PHARM INC (US) 2022-09-21 EP claimed
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2022-08-04 US claimed
US-12635625-B2 Bioceramic and carbon-based hydroponic systems, methods and devices MULTIPLE ENERGY TECHNOLOGIES LLC 2026-05-26 US disclosed
US-20260115182-A1 PAPD5 INHIBITORS AND METHODS OF USE THEREOF CHILDRENS MEDICAL CENTER (US) 2026-04-30 US disclosed
US-12605470-B2 Nanodroplet with layer-by-layer assembly ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2026-04-21 US disclosed
US-20260083770-A1 RNA COMPLEXES AND NANOSTRUCTURES FOR TREATMENT OF CANCER METASTASIS OHIO STATE INNOVATION FOUNDATION (US) 2026-03-26 US disclosed
EP-4714496-A2 TREATMENT OF NEURONAL CEROID LIPOFUSCINOSIS OrfoNeuro ApS (DK) 2026-03-25 EP disclosed
US-20260077027-A1 PEPTIDE AND NUCLEIC ACID METHODS TO MODULATE DELIVERY OF NUCLEIC ACID STRUCTURES, POLYPEPTIDES, AND THEIR CARGOES OHIO STATE INNOVATION FOUNDATION (US) 2026-03-19 US disclosed
US-12577282-B2 Galectin-1/ galectin-3 chimeras and multivalent proteins UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-03-17 US disclosed
US-11324758-B2 Formulation and process for limiting nerve trauma INTRAVITAL PTY LTD (AU) 2022-05-10 US disclosed
WO-2022076932-A1 COMPOSITIONS AND METHODS OF TREATING A PI3K MEDIATED DISEASE VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 2022-04-14 WO disclosed
WO-2022072348-A1 STROKE TREATMENT OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2022-04-07 WO disclosed
US-20220106580-A1 TARGETED CHONDROITINASE ABC FUSION PROTEINS AND COMPLEXES THEREOF UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2022-04-07 US disclosed
US-20220098258-A1 GALECTIN-1/ GALECTIN-3 CHIMERAS AND MULTIVALENT PROTEINS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2022-03-31 US disclosed
CN-108366947-B Compositions and methods for PDE3A or SLFN12 expressing cancers 布罗德研究所股份有限公司 2022-03-29 CN disclosed
WO-2022036063-A2 COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES THE BROAD INSTITUTE, INC. (US) 2022-02-17 WO disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577282-B2 Galectin-1/ galectin-3 chimeras and multivalent proteins LGALS1, LGALS3BP, LGALS3 PDE10A 3466/4885PDE3A 2960/4885PDE3B 2702/4885
US-20260115182-A1 PAPD5 INHIBITORS AND METHODS OF USE THEREOF POT1, TERT, BRCA1 PDE10A 4558/4885PDE3A 4521/4885PDE3B 4623/4885
US-20260083770-A1 RNA COMPLEXES AND NANOSTRUCTURES FOR TREATMENT OF CANCER METASTASIS RNMT, NSUN2, FBL PDE10A 3909/4885PDE3A 4353/4885PDE3B 4422/4885
US-12635625-B2 Bioceramic and carbon-based hydroponic systems, methods and devices CNR2, WNT1, CNR1 PDE10A 1829/4885PDE3A 3582/4885PDE3B 4292/4885
US-20260077027-A1 PEPTIDE AND NUCLEIC ACID METHODS TO MODULATE DELIVERY OF NUCLEIC ACID STRUCTURES, POLYPEPTIDES, AND THEIR CARGOES MICA, PDCD1LG2, TLR9 PDE10A 4246/4885PDE3A 4571/4885PDE3B 4410/4885
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS CNR2, CNR1, OPRL1 PDE10A 957/4885PDE3A 1429/4885PDE3B 1494/4885
US-11771695-B2 Cannabinoid receptor modulators CNR2, CNR1, OPRL1 PDE10A 957/4885PDE3A 1429/4885PDE3B 1494/4885
US-12605470-B2 Nanodroplet with layer-by-layer assembly FLNB, FLNA, DAGLB PDE10A 340/4885PDE3A 1371/4885PDE3B 1185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.