Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312842 | 0.79 | HPGD (0.61) | HPGD | |
| SCHEMBL9311363 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RAB9ALMNAMAPT | |
| SCHEMBL22727838 | 0.76 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2RAB9ALMNA | |
| SCHEMBL9312614 | 0.76 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2RAB9ALMNA | |
| SCHEMBL9312922 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4ERAB9ALMNAMAPT | |
| SCHEMBL22727837 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2LMNACYP2A6 | |
| SCHEMBL22727836 | 0.73 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2RAB9AMAPT | |
| SCHEMBL8314306 | 0.71 | PARP15 (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL3718600 | 0.71 | PARP15 (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL8312964 | 0.71 | PARP15 (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |