Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312614 | 0.93 | ALDH1A1 (0.38) | ALDH1A1HSD17B10TDP1HPGDMIF | |
| SCHEMBL9429827 | 0.82 | HPGD (0.61) | HPGDMAOBPYGLKDM4E | |
| SCHEMBL9311363 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HPGDGRIN2CMIFMAOB | |
| SCHEMBL9312276 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HPGDMIFKDM4EMAPT | |
| SCHEMBL9429040 | 0.75 | PYGL (0.56) | HPGDMAOBPYGL | |
| SCHEMBL9429648 | 0.73 | FFAR1 (0.48) | ALDH1A1HSD17B10TDP1HPGDCYP3A4 | |
| SCHEMBL9393510 | 0.69 | HPGD (0.65) | ALDH1A1HSD17B10TDP1HPGDCYP3A4 | |
| SCHEMBL30023457 | 0.69 | HPGD (0.65) | ALDH1A1HSD17B10TDP1HPGDCYP3A4 | |
| SCHEMBL31708214 | 0.68 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EMAPTLMNA | |
| SCHEMBL29209169 | 0.68 | MAOB (0.57) | ALDH1A1HSD17B10TDP1HPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |