SCHEMBL9312331

SCHEMBL9312331

C[C@H]1CNCC[C@]1(O)c1cccc(F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.45
SLC6A3 Q01959 3/20 0.45
SLC6A2 P23975 2/20 0.45
CHRNA1 P02708 1/20 0.45
CHRNB1 P11230 1/20 0.45
CHRNB2 P17787 1/20 0.45
CHRNB4 P30926 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA4 P43681 1/20 0.45
REN P00797 6/20 0.43
CYP3A4 P08684 5/20 0.43
KCNH2 Q12809 5/20 0.43
MC4R P32245 1/20 0.41
KDM1A O60341 2/20 0.40
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
CCR2 P41597 1/20 0.38
SLC6A9 P48067 1/20 0.38
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9312333 1.00 SLC6A4 (0.45) SLC6A4SLC6A3SLC6A2CHRNA1CHRNB1
SCHEMBL9312339 1.00 SLC6A4 (0.45) SLC6A4SLC6A3SLC6A2CHRNA1CHRNB1
SCHEMBL9310839 0.84 CHRNA1 (0.45) SLC6A3SLC6A2CHRNA1CHRNB1CHRNB2
SCHEMBL9310842 0.84 CHRNA1 (0.45) SLC6A3SLC6A2CHRNA1CHRNB1CHRNB2
SCHEMBL9310851 0.84 CHRNA1 (0.45) SLC6A3SLC6A2CHRNA1CHRNB1CHRNB2
SCHEMBL9310455 0.83 REN (0.46) SLC6A4SLC6A3SLC6A2CHRNA1CHRNB1
SCHEMBL4073117 0.82 SLC6A3 (0.40) SLC6A3SLC6A2CHRNA1CHRNB1CHRNB2
SCHEMBL4885831 0.82 SLC6A3 (0.40) SLC6A3SLC6A2CHRNA1CHRNB1CHRNB2
SCHEMBL4603160 0.82 OPRM1 (0.47) SLC6A3SLC6A2CHRNB2CHRNB4CHRNA3
SCHEMBL11768776 0.82 OPRM1 (0.47) SLC6A3SLC6A2CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292738-A Anti-virally active pyridazinamines JANSSEN PHARMACEUTICA N.V. (BE) 1994-03-08 US disclosed
US-5157035-A Viricides JANSSEN PHARMACEUTICA N. V. (BE) 1992-10-20 US disclosed
US-5001125-A Anti-virally active pyridazinamines JANSSEN PHARMACEUTICA N.V. (BE) 1991-03-19 US disclosed
EP-0156433-B1 ANTI-VIRALLY ACTIVE PYRIDAZINAMINES JANSSEN PHARMACEUTICA N.V. (BE) 1991-02-27 EP disclosed
EP-0156433-A2 Anti-virally active pyridazinamines JANSSEN PHARMACEUTICA N.V. (BE) 1985-10-02 EP disclosed