Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | APP | P05067 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372905 | 0.83 | OPRM1 (0.47) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL9310449 | 0.82 | L3MBTL1 (0.59) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL9528495 | 0.80 | APP (0.66) | L3MBTL1ALDH1A1APPPSEN1PSEN2 | |
| SCHEMBL6816262 | 0.80 | L3MBTL1 (0.60) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL14107981 | 0.79 | L3MBTL1 (0.59) | L3MBTL1MAPTALDH1A1APPGAA | |
| SCHEMBL5824190 | 0.78 | L3MBTL1 (0.57) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL4981287 | 0.78 | L3MBTL1 (0.57) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL7570603 | 0.77 | L3MBTL1 (0.56) | L3MBTL1MAPTALDH1A1APPGAA | |
| SCHEMBL4668387 | 0.76 | L3MBTL1 (0.55) | L3MBTL1MAPTALDH1A1APPLMNA | |
| SCHEMBL31559556 | 0.76 | SMN1; SMN2 (0.50) | L3MBTL1ALDH1A1APPHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |