Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.42 |
| ▸ | ITGAV | P06756 | 12/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312021 | 0.81 | HPGD (0.61) | HPGD | |
| SCHEMBL9312031 | 0.79 | HPGD (0.48) | HPGD | |
| SCHEMBL5413870 | 0.74 | PPARG (0.58) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL9430175 | 0.73 | PPARG (0.40) | HPGDITGB3ITGAVITGB6ITGB5 | |
| SCHEMBL9430167 | 0.73 | PPARG (0.62) | ALDH1A1HPGDMAPT | |
| SCHEMBL8800183 | 0.72 | CYSLTR1 (0.51) | ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL8196269 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL30599264 | 0.69 | HPGD (0.64) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL3258559 | 0.69 | HPGD (0.64) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL9312593 | 0.69 | ALDH1A3 (0.45) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |