Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.59 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30162751 | 0.97 | EPHX2 (0.59) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL930213 | 0.97 | EPHX2 (0.59) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL931638 | 0.95 | EPHX2 (0.57) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL9005535 | 0.95 | EPHX2 (0.57) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL30575465 | 0.95 | EPHX2 (0.57) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL930820 | 0.95 | EPHX2 (0.57) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL29505911 | 0.93 | EPHX2 (0.65) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL17573001 | 0.86 | HRH1 (0.60) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL9005597 | 0.86 | EPHX2 (0.58) | EPHX2KAT6AAKR1C3GRIK1GRIA2 | |
| SCHEMBL1168318 | 0.86 | EPHX2 (0.55) | EPHX2KAT6AAKR1C3GRIK1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120183660-A1 | ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS | SENOMYX, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| EP-2448944-A2 | ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS | Senomyx, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002871-A2 | ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS | SENOMYX, INC (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183660-A1 | ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS | TAS2R41, TAS2R42, TAS2R40 | EPHX2 3910/4885KAT6A 2720/4885AKR1C3 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.