SCHEMBL931447

SCHEMBL931447

CC/C=C\C/C=C\C/C=C\CCCCCCCCOCCCN(C)C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
F7 P08709 2/20 0.44
F3 P13726 2/20 0.44
MAPT P10636 2/20 0.44
CYP19A1 P11511 2/20 0.44
CYP3A4 P08684 2/20 0.44
ALOX15 P16050 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
OXER1 Q8TDS5 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
FFAR1 O14842 1/20 0.44
NR1I2 O75469 1/20 0.44
LMNA P02545 1/20 0.44
PLA2G1B P04054 1/20 0.44
HPGD P15428 1/20 0.44
PTGS1 P23219 1/20 0.44
PTGS2 P35354 1/20 0.44
PPARG P37231 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23017141 1.00 ALDH1A1 (0.44) ALDH1A1F7F3MAPTCYP19A1
SCHEMBL13285504 0.90 ALDH1A1 (0.47) ALDH1A1
SCHEMBL28515320 0.90 ALDH1A1 (0.47) ALDH1A1
SCHEMBL130135 0.88 ALDH1A1 (0.53) ALDH1A1F7F3MAPTCYP19A1
SCHEMBL19866319 0.87 DNM1 (0.50) ALDH1A1
SCHEMBL10434947 0.86 ALDH1A1 (0.52) ALDH1A1F7F3MAPTCYP19A1
SCHEMBL15894688 0.84 DNM1 (0.50) LPAR2LPAR3LPAR1
SCHEMBL4602557 0.84 ALDH1A1 (0.48) ALDH1A1KDM4ETSHRLPAR2LPAR3
SCHEMBL19809760 0.83 ALDH1A1 (0.47) ALDH1A1
SCHEMBL17107448 0.82 LPAR2 (0.57) ALDH1A1F7F3MAPTCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3329003-A2 COMPOSITIONS AND METHODS FOR SILENCING HEPATITIS B VIRUS GENE EXPRESSION Arbutus Biopharma Corporation (CA) 2018-06-06 EP claimed
WO-2017019891-A2 COMPOSITIONS AND METHODS FOR SILENCING HEPATITIS B VIRUS GENE EXPRESSION PROTIVA BIOTHERAPEUTICS, INC. (CA) 2017-02-02 WO claimed
WO-2016197133-A1 DELIVERING CRISPR THERAPEUTICS WITH LIPID NANOPARTICLES PROTIVA BIOTHERAPEUTICS, INC. (CA) 2016-12-08 WO claimed
WO-2016154127-A2 COMPOSITIONS AND METHODS FOR TREATING HYPERTRIGLYCERIDEMIA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2016-09-29 WO claimed
EP-2506879-A1 SNALP FORMULATIONS CONTAINING ANTIOXIDANTS Protiva Biotherapeutics Inc. (CA) 2012-10-10 EP claimed
EP-2480668-A2 COMPOSITIONS AND METHODS FOR SILENCING GENES EXPRESSED IN CANCER Protiva Biotherapeutics Inc. (CA) 2012-08-01 EP claimed
WO-2011066651-A1 SNALP FORMULATIONS CONTAINING ANTIOXIDANTS PROTIVA BIOTHERAPEUTICS, INC. (CA) 2011-06-09 WO claimed
WO-2011038160-A2 COMPOSITIONS AND METHODS FOR SILENCING GENES EXPRESSED IN CANCER PROTIVA BIOTHERAPEUTICS, INC. (CA) 2011-03-31 WO claimed
EP-4347836-A2 COMPOSITIONS AND METHODS FOR SILENCING CARBONIC ANHYDRASE 2 EXPRESSION Alnylam Pharmaceuticals, Inc. (US) 2024-04-10 EP disclosed
EP-4333898-A2 PEPTIDE-LIPID CONJUGATES Arcturus Therapeutics, Inc. (US) 2024-03-13 EP disclosed
WO-2023218420-A1 MRNA COMPOSITIONS FOR INDUCING LATENT HIV-1 REVERSAL Janssen Pharmaceuticals, Inc. (US) 2023-11-16 WO disclosed
EP-4178613-A1 RNA REPLICON VACCINES AGAINST HBV Janssen Sciences Ireland Unlimited Company (IE) 2023-05-17 EP disclosed
EP-4157344-A2 MULTIVALENT NUCLEIC ACID BASED CORONAVIRUS VACCINES CureVac SE (DE) 2023-04-05 EP disclosed
EP-3986452-A1 ROTAVIRUS MRNA VACCINE CureVac AG (DE) 2022-04-27 EP disclosed
WO-2017140905-A1 ZIKA VIRUS VACCINE CUREVAC AG (DE) 2017-08-24 WO disclosed
WO-2016079197-A1 DELIVERY ENHANCERS FOR CONJUGATED SIRNA AND LIPID NANOPARTICLES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2016-05-26 WO disclosed
WO-2014008334-A1 STABLE NON-AGGREGATING NUCLEIC ACID LIPID PARTICLE FORMULATIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2014-01-09 WO disclosed
EP-2449106-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B Protiva Biotherapeutics Inc. (CA) 2012-05-09 EP disclosed
WO-2011141704-A1 NOVEL CYCLIC CATIONIC LIPIDS AND METHODS OF USE PROTIVA BIOTHERAPEUTICS, INC (CA) 2011-11-17 WO disclosed
WO-2011000108-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS, INC. (CA) 2011-01-06 WO disclosed