Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.70 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10433444 | 0.88 | CES1 (0.70) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL27390589 | 0.83 | CES1 (0.63) | CES1CES2AKR1B1PAMMEN1 | |
| SCHEMBL1042453 | 0.83 | CES1 (1.00) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL5709778 | 0.83 | CES1 (1.00) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL7808017 | 0.80 | KEAP1 (0.55) | CES1HDAC8HDAC6FAAHMAPT | |
| SCHEMBL16405134 | 0.79 | CES1 (0.70) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL28262992 | 0.79 | CES1 (0.59) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL13498524 | 0.79 | CES1 (0.70) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL9770614 | 0.76 | CES1 (0.66) | CES1CES2AKR1B1PTPN1PAM | |
| SCHEMBL1033375 | 0.75 | CES1 (0.64) | CES1CES2AKR1B1PTPN1PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5300527-A | Administering anticholinergic agents for treating the memory dysfunction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-05 | — | — | US | disclosed |
| US-5177111-A | Analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0432719-A1 | Alkylamino- and alkylaminoalkyl diarylketones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-06-19 | — | — | EP | disclosed |
| US-5006563-A | Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |